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Article

Identification of mutations in DNA polymerase beta mRNAs from patients with Werner syndrome.

Biochemical and biophysical research communications - 15 Apr 1994

Sadakane Y, Maeda K, Kuroda Y, Hori K

Abstract excerpt

Werner syndrome (WS) is a rare autosomal recessive disorder characterized by prematurely aged appearance. Genetic linkage analysis has placed the relevant gene in subchromosomal band 8p12. DNA polymerase beta gene has been mapped to chromosome 8p12-11 and thought to be involved in DNA repair and possibly in recombination. Somatic cells from WS patients exhibit chromosomal instability, a markedly reduced...

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Identifiers

PMID: 7545922
DOI: 10.1006/bbrc.1994.1437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Identification of mutations in DNA polymerase beta mRNAs from patients with Werner syndrome.PMID 7545922Read ↗

Werner syndrome gene variants in human sarcomas.Semantic proximity Read ↗

Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group.Semantic proximity Read ↗

The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis.Semantic proximity Read ↗

Gene expression profiling in Werner syndrome closely resembles that of normal agingSemantic proximity Read ↗

Positional cloning of the Werner's syndrome gene.Semantic proximity Read ↗

A novel mutation of the WRN gene in a Chinese patient with Werner syndrome.Semantic proximity Read ↗

The enzymatic activities of the Werner syndrome protein are disabled by the amino acid polymorphism R834C.Semantic proximity Read ↗

A novel compound heterozygous mutation in Werner syndrome results in WRN transcript decay.Semantic proximity Read ↗

Diverse gene sequences are overexpressed in werner syndrome fibroblasts undergoing premature replicative senescence.Semantic proximity Read ↗

Homozygosity for the WRN Helicase-Inactivating Variant, R834C, does not confer a Werner syndrome clinical phenotype.Semantic proximity Read ↗

The Werner syndrome protein is involved in RNA polymerase II transcription.Semantic proximity Read ↗

Comparison of methods for identifying transcription units and transcription map of the Werner syndrome gene region.Semantic proximity Read ↗

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