Identification of mutations in DNA polymerase beta mRNAs from patients with Werner syndrome.

doi:10.1006/bbrc.1994.1437

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Article

Identification of mutations in DNA polymerase beta mRNAs from patients with Werner syndrome.

Biochemical and biophysical research communications - 15 Apr 1994

Sadakane Y, Maeda K, Kuroda Y, Hori K

Abstract excerpt

Werner syndrome (WS) is a rare autosomal recessive disorder characterized by prematurely aged appearance. Genetic linkage analysis has placed the relevant gene in subchromosomal band 8p12. DNA polymerase beta gene has been mapped to chromosome 8p12-11 and thought to be involved in DNA repair and possibly in recombination. Somatic cells from WS patients exhibit chromosomal instability, a markedly reduced...

Topics

Amino Acid Sequence
Base Sequence
Blotting, Southern
Chromosome Banding
Chromosome Mapping
Chromosomes, Human, Pair 8
Cloning, Molecular
DNA
DNA Polymerase I
DNA Primers
DNA Transposable Elements

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA, Complementary

Exons

Female

Humans

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 7545922
DOI: 10.1006/bbrc.1994.1437

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7545922-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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