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Article

IL-4 plus CD40 monoclonal antibody induces human B cells γ subclass-specific isotype switch: switching to γ 1, γ 3, and γ 4, but not γ 2

1 Sept 1995

Abstract excerpt

Stimulation with IL-4 plus CD40 mAb is known to induce production of IgE and IgG4. In this study, we determined the IgG subclass specificity of IL-4 plus CD40 mAb stimulation for human purified B cells. We determined true in vitro switching by the generation of switch circular DNA (S gamma/S mu) representing primary S mu/S gamma events and production of gamma subclass-specific germ-line transcripts by a...

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Identifiers

PMID: 7544371
DOI: 10.4049/jimmunol.155.5.2318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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