Article
Clonally related IgE and IgG4 transcripts in blood lymphocytes of patients with asthma reveal differing patterns of somatic mutation.
European journal of immunology - 1 Oct 1998
Snow R E, Chapman C J, Holgate S T, Stevenson F K
Abstract excerpt
Isotype switching to IgE contributes to atopic asthma, therefore strategies to divert this process to alternative isotypes could have therapeutic relevance. It is known that patients with allergic disease have serum IgE and IgG4 antibodies with similar specificities, and that cytokines such as IL...
Topics
- Amino Acid Sequence
- Asthma
- Base Sequence
- DNA, Complementary
- Genetic Variation
- Humans
- Immunoglobulin E
- Immunoglobulin G
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Lymphocytes
- Molecular Sequence Data
- Mutation
- RNA, Messenger