Article
Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug-resistant strains than lamivudine in vitro.
PloS one - 1 Jan 2014
Wang Rui-Rui, Yang Qing-Hua, Luo Rong-Hua, Peng You-Mei, Dai Shao-Xing, Zhang Xing-Jie, Chen Huan, Cui Xue-Qing, Liu Ya-Juan, Huang Jing-Fei, Chang Jun-Biao, Zheng Yong-Tang
Abstract excerpt
Azvudine is a novel nucleoside reverse transcriptase inhibitor with antiviral activity on human immunodeficiency virus, hepatitis B virus and hepatitis C virus. Here we reported the in vitro activity of azvudine against HIV-1 and HIV-2 when used alone or in combination with other antiretroviral drugs and its drug resistance features. Azvudine exerted highly potent inhibition on HIV-1 (EC(50)s ranging from 0.03 to...
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