Article
Cystic fibrosis transmembrane conductance regulator and the etiology and pathogenesis of cystic fibrosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 1992
McIntosh I, Cutting G R
Abstract excerpt
Cystic fibrosis (CF) is an inherited disorder causing pancreatic, pulmonary, and sinus disease in children and young adults. Abnormal viscosity of mucous secretions is a hallmark of the disease, and is believed to be the result of altered electrolyte transport across epithelial cell membranes. The monogenic etiology of this disease has been apparent for more than 40 years, but the defective gene has only recently...
Topics
- Amino Acid Sequence
- Chlorine
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Humans
- Intestinal Mucosa
- Ion Channels
- Male
- Membrane Proteins
- Molecular Sequence Data