Article
The product of HUM1, a novel yeast gene, is required for vacuolar Ca2+/H+ exchange and is related to mammalian Na+/Ca2+ exchangers.
Molecular and cellular biology - 1 Jul 1996
Pozos T C, Sekler I, Cyert M S
Abstract excerpt
Calcineurin, or PP2B, plays a critical role in mediating Ca2+-dependent signaling in many cell types. In yeast cells, this highly conserved protein phosphatase regulates aspects of ion homeostasis and cell wall synthesis. We show that calcineurin mutants are sensitive to high concentrations of Mn...
Topics
- Adenosine Triphosphatases
- Amino Acid Sequence
- Animals
- Antiporters
- Base Sequence
- Calcineurin
- Calcium
- Calmodulin-Binding Proteins
- Carrier Proteins
- Cattle
- Dogs
- Genes, Fungal
- Genomic Library
- Genotype
- Intracellular Membranes
- Mammals
- Molecular Sequence Data
- Myocardium