Article
Sensitivity/resistance profile of a simian immunodeficiency virus containing the reverse transcriptase gene of human immunodeficiency virus type 1 (HIV-1) toward the HIV-1-specific non-nucleoside reverse transcriptase inhibitors.
Biochemical and biophysical research communications - 26 Jun 1995
Balzarini J, Weeger M, Camarasa M J, De Clercq E, Uberla K
Abstract excerpt
To develop an animal model for the therapy of AIDS with human immunodeficiency virus type 1 (HIV-1)-specific reverse transcriptase (RT) inhibitors, we recently constructed a hybrid simian immunodeficiency virus (SIV)/HIV-1 in which the RT gene of SIV was replaced by the RT gene of HIV-1. This chimaeric virus, designated RT-SHIV, was found to be markedly sensitive to the inhibitory effects of both nucleoside (ddN)...
Topics
- Acquired Immunodeficiency Syndrome
- Antiviral Agents
- Base Sequence
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Drug Evaluation, Preclinical
- Drug Resistance, Microbial
- HIV Reverse Transcriptase
- HIV-1