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Article

Efavirenz therapy in rhesus macaques infected with a chimera of simian immunodeficiency virus containing reverse transcriptase from human immunodeficiency virus type 1.

Antimicrobial agents and chemotherapy - 1 Sept 2004

Hofman Michael J, Higgins Joanne, Matthews Timothy B, Pedersen Niels C, Tan Chalet, Schinazi Raymond F, North Thomas W

Abstract excerpt

The specificity of nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) for the RT of human immunodeficiency virus type 1 (HIV-1) has prevented the use of simian immunodeficiency virus (SIV) in the study of NNRTIs and NNRTI-based highly active antiretroviral therapy. However, a SIV-HIV-1 chimera (RT-SHIV), in which the RT from SIVmac239 was replaced with the RT-encoding region from HIV-1, is susceptible...

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Identifiers

PMID: 15328115
DOI: 10.1128/AAC.48.9.3483-3490.2004
PMCID: PMC514752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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