Efavirenz therapy in rhesus macaques infected with a chimera of simian immunodeficiency virus containing reverse transcriptase from human immunodeficiency virus type 1.

doi:10.1128/AAC.48.9.3483-3490.2004

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Article

Efavirenz therapy in rhesus macaques infected with a chimera of simian immunodeficiency virus containing reverse transcriptase from human immunodeficiency virus type 1.

Antimicrobial agents and chemotherapy - 1 Sept 2004

Hofman Michael J, Higgins Joanne, Matthews Timothy B, Pedersen Niels C, Tan Chalet, Schinazi Raymond F, North Thomas W

Abstract excerpt

The specificity of nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) for the RT of human immunodeficiency virus type 1 (HIV-1) has prevented the use of simian immunodeficiency virus (SIV) in the study of NNRTIs and NNRTI-based highly active antiretroviral therapy. However, a SIV-HIV-1 chimera (RT-SHIV), in which the RT from SIVmac239 was replaced with the RT-encoding region from HIV-1, is susceptible...

Topics

Alkynes
Animals
Benzoxazines
CD4-CD8 Ratio
Chimera
Cyclopropanes
DNA Primers
DNA, Viral
Drug Resistance, Viral
Flow Cytometry
HIV Reverse Transcriptase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HeLa Cells

Humans

Macaca mulatta

Mutation

Oxazines

RNA, Viral

Reverse Transcriptase Inhibitors

Source

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Identifiers

PMID: 15328115
DOI: 10.1128/AAC.48.9.3483-3490.2004
PMCID: PMC514752

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