Article
SIV/HIV-1 hybrid virus expressing the reverse transcriptase gene of HIV-1 remains sensitive to HIV-1-specific reverse transcriptase inhibitors after passage in rhesus macaques.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association - 1 May 1997
Balzarini J, De Clercq E, Uberla K
Abstract excerpt
We have previously described an animal model for the therapy of human immunodeficiency virus type 1 (HIV-1) infection with HIV-1-specific reverse transcriptase (RT) inhibitors based on a simian immunodeficiency virus (SIV), in which the RT gene of SIV was replaced by the RT gene of HIV-1. In vitr...
Topics
- Animals
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Hybridization, Genetic
- Macaca mulatta
- Mutation
- Reverse Transcriptase Inhibitors
- Simian Immunodeficiency Virus