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Article

Variation of human immunodeficiency virus type-1 reverse transcriptase within the simian immunodeficiency virus genome of RT-SHIV.

PloS one - 1 Jan 2014

Wadford Debra A, Kauffman Robert C, Deere Jesse D, Aoki Scott T, Stanton Richard A, Higgins Joanne, Van Rompay Koen K A, Villalobos Andradi, Nettles James H, Schinazi Raymond F, Pedersen Niels C, North Thomas W

Abstract excerpt

RT-SHIV is a chimera of simian immunodeficiency virus (SIV) containing the reverse transcriptase (RT)-encoding region of human immunodeficiency virus type 1 (HIV-1) within the backbone of SIVmac239. It has been used in a non-human primate model for studies of non-nucleoside RT inhibitors (NNRTI) and highly active antiretroviral therapy (HAART). We and others have identified several mutations that arise in the...

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Identifiers

PMID: 24498008
DOI: 10.1371/journal.pone.0086997
PMCID: PMC3909041

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Source receipt: pubmed, retrieved 7 Sept 2026.

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