Novel mutation in 16S rRNA associated with streptomycin dependence in Mycobacterium tuberculosis.

doi:10.1128/AAC.39.3.769

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Article

Novel mutation in 16S rRNA associated with streptomycin dependence in Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 Mar 1995

Honoré N, Marchal G, Cole S T

Abstract excerpt

Molecular characterization of a streptomycin-dependent mutant of Mycobacterium tuberculosis revealed the presence of a novel mutation in the rrs gene encoding 16S rRNA. Insertion of an additional cytosine in the 530 loop of 16S rRNA, a region known to be involved in streptomycin susceptibility an...

Topics

Base Sequence
DNA, Bacterial
Drug Resistance, Microbial
Molecular Sequence Data
Mutation
Mycobacterium tuberculosis
Nucleic Acid Conformation
Polymerase Chain Reaction
RNA, Bacterial
RNA, Ribosomal
Streptomycin

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