Article
Hepatitis B virus precore mutations and HBeAg negative reactivation of chronic hepatitis B after interferon therapy.
Liver - 1 Apr 1995
Talbodec N, Loriot M A, Gigou M, Guigonis V, Boyer N, Bezeaud A, Erlinger S, Benhamou J P, Marcellin P
Abstract excerpt
The objective of this study was to look for HBV precore mutations in three patients with chronic active hepatitis B who developed HBV-DNA-positive/HBeAg-negative reactivation after HBe seroconversion induced by interferon therapy. Direct sequencing of polymerase chain reaction products was performed on serum collected before and after HBe seroconversion. In two patients precore sequence showed only wild-type HBV...
Topics
- Adult
- Base Sequence
- Chronic Disease
- Hepatitis B
- Hepatitis B e Antigens
- Hepatitis B virus
- Humans
- Interferons
- Male
- Middle Aged
- Molecular Sequence Data