Article
Precore mutant hepatitis B virus and outcome of chronic infection and hepatitis in hepatitis B e antigen-positive children.
Pediatric research - 1 Sept 1994
Barbera C, Calvo P, Coscia A, Perugini L, Dastoli G, Randone A, Bonino F, Brunetto M R
Abstract excerpt
Mutant hepatitis B virus (HBV), responsible for the lack of hepatitis B virus "e" antigen (HBeAg) secretion because of a translational stop codon at nucleotide 1896 of the HBV-DNA precore region (HBeAg minus HBV), has been detected worldwide in acute and chronic HBV infections and diseases. HBeAg minus HBV appears to condition the outcome of infection and to be involved in the pathogenesis of hepatitis B. We...
Topics
- Adolescent
- Base Sequence
- Child
- Child, Preschool
- Chronic Disease
- DNA, Viral
- Female
- Follow-Up Studies
- Hepatitis B
- Hepatitis B Surface Antigens
- Hepatitis B e Antigens