Analysis of the RNA- and DNA-dependent DNA polymerase activities of point mutants of HIV-1 reverse transcriptase lacking ribonuclease H activity.

doi:10.1021/bi00107a019

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Article

Analysis of the RNA- and DNA-dependent DNA polymerase activities of point mutants of HIV-1 reverse transcriptase lacking ribonuclease H activity.

Biochemistry - 29 Oct 1991

Dudding L R, Nkabinde N C, Mizrahi V

Abstract excerpt

The RNA- and DNA-dependent DNA polymerase activities of two point mutants of HIV-1 reverse transcriptase lacking ribonuclease H activity have been compared to the wild-type enzyme activities using substrates consisting of an oligodeoxynucleotide primer hybridized to either a RNA or a DNA template...

Topics

Base Sequence
DNA-Directed DNA Polymerase
Electrophoresis, Polyacrylamide Gel
Gene Products, gag
HIV-1
Kinetics
Molecular Sequence Data
Mutation
RNA-Directed DNA Polymerase
Ribonuclease H

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