Premature strand transfer by the HIV-1 reverse transcriptase during strong-stop DNA synthesis.

doi:10.1093/nar/22.2.137

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Article

Premature strand transfer by the HIV-1 reverse transcriptase during strong-stop DNA synthesis.

Nucleic acids research - 25 Jan 1994

Klaver B, Berkhout B

Abstract excerpt

Reverse transcription of retroviral genomes starts near the 5' end of the viral RNA by use of an associated tRNA primer. According to the current model of reverse transcription, the initial cDNA product, termed minus-strand strong-stop DNA, 'jumps' to a repeated sequence (R region) at the 3' end...

Topics

Base Sequence
Cell Line
DNA, Viral
HIV Long Terminal Repeat
HIV Reverse Transcriptase
HIV-1
Molecular Sequence Data
Mutation
RNA, Viral
RNA-Directed DNA Polymerase
Recombination, Genetic
Templates, Genetic
Transcription, Genetic

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