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Article

Fulminant reactivation of hepatitis B due to envelope protein mutant that escaped detection by monoclonal HBsAg ELISA.

Lancet (London, England) - 3 Jun 1995

Carman W F, Korula J, Wallace L, MacPhee R, Mimms L, Decker R

Abstract excerpt

The detection of a fatal case of reactivation of hepatitis B, in a previously vaccinated Indonesian patient after withdrawal of chemotherapy for lymphoma, was delayed because HBsAg was negative in a widely used monoclonal-antibody-based ELISA. The serum was later found to be strongly reactive for...

Topics

Amino Acid Sequence
Enzyme-Linked Immunosorbent Assay
Fatal Outcome
Hepacivirus
Hepatitis Antibodies
Hepatitis B
Hepatitis B Surface Antigens
Hepatitis B virus
Hepatitis C Antibodies
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

Viral Envelope Proteins

Source

Identifiers

PMID: 7539089
DOI: 10.1016/s0140-6736(95)92599-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7539089-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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