A human hybridoma monoclonal antibody (TrJ11) recognizing a new HLA-DR epitope shared by DR4, DR8, DR11, and DRB1*1303.

doi:10.1016/0198-8859(94)00083-3

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Article

A human hybridoma monoclonal antibody (TrJ11) recognizing a new HLA-DR epitope shared by DR4, DR8, DR11, and DRB1*1303.

Human immunology - 1 Jan 1995

Ge J, Bratlie A, Hannestad K

Abstract excerpt

The cytotoxic IgM lambda human hybridoma mAb TrJ11 reacts with lymphoblastoid B-cell lines expressing DR4, DR8, DR11, and DRB1*1303. However, TrJ11 was monospecific when normal B cells freshly isolated from blood served as targets in that it only killed HLA-DR4-positive cells. Thus, of 235 HLA-typed persons TrJ11 was strongly cytotoxic for normal B cells of all 90 DR4-positive individuals, but it did not react...

Topics

Alleles
Animals
Antibodies, Monoclonal
Autoimmune Diseases
B-Lymphocytes
Cell Line, Transformed
Disease Susceptibility
Epitopes
Genetic Predisposition to Disease
HLA-DR Antigens
HLA-DR Serological Subtypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DR4 Antigen

HLA-DRB1 Chains

Humans

Hybridomas

Immunoglobulin M

Mice

Source

Open in PubMed

Identifiers

PMID: 7538497
DOI: 10.1016/0198-8859(94)00083-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7538497-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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