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Article

Nickel-induced transcriptional changes persist post exposure through epigenetic reprogramming

1 Dec 2019

Abstract excerpt

BACKGROUND: Nickel is an occupational and environmental toxicant associated with a number of diseases in humans including pulmonary fibrosis, bronchitis and lung and nasal cancers. Our earlier studies showed that the nickel-exposure-induced genome-wide transcriptional changes, which persist even after the termination of exposure may underlie nickel pathogenesis. However, the mechanisms that drive nickel-induced...

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PMID: 31856895
DOI: 10.1186/s13072-019-0324-3

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