Substitution of an aspartic acid results in constitutive activation of c-kit receptor tyrosine kinase in a rat tumor mast cell line RBL-2H3.

doi:10.1159/000236870

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Article

Substitution of an aspartic acid results in constitutive activation of c-kit receptor tyrosine kinase in a rat tumor mast cell line RBL-2H3.

International archives of allergy and immunology - 1 Apr 1995

Tsujimura T, Furitsu T, Morimoto M, Kanayama Y, Nomura S, Matsuzawa Y, Kitamura Y, Kanakura Y

Abstract excerpt

The c-kit protooncogene encodes a receptor tyrosine kinase that mediates signals required for differentiation, proliferation and survival of mast cells. We have already shown the constitutive activation of c-kit receptor tyrosine kinase (KIT) in a human mast cell leukemia line (HMC-1) and a murin...

Topics

Amino Acid Sequence
Animals
Aspartic Acid
Base Sequence
DNA, Complementary
Humans
Mice
Molecular Sequence Data
Mutation
Oligonucleotides, Antisense
Phosphorylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-kit

Rats

Receptor Protein-Tyrosine Kinases

Receptors, Colony-Stimulating Factor

Transfection

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 7536501
DOI: 10.1159/000236870

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7536501-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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