Article
In vivo differentiation of mast cells from acute myeloid leukemia blasts carrying a novel activating ligand-independent C-kit mutation.
Blood cells, molecules & diseases - 1 Jun 1998
Beghini A, Cairoli R, Morra E, Larizza L
Abstract excerpt
The primary role of protooncogene c-kit in mast cell differentiation is supported by the development of mast cells from CD34+/CD117+(c-kit) myeloid precursors. Growth factor independence, neoplastic transformation and differentiation of mast cells were found in association with c-kit activating m...
Topics
- Alleles
- Amino Acid Substitution
- Animals
- Antigens, CD34
- Bone Marrow
- Cell Differentiation
- Cell Division
- DNA, Neoplasm
- Disease Progression
- Fatal Outcome
- Gene Expression Regulation, Leukemic
- Humans
- Leukemia, Mast-Cell
- Leukemia, Myeloid, Acute
- Male
- Mast Cells
- Mast-Cell Sarcoma
- Mice