Article
Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis.
Gut - 1 Jan 1995
Mulder J W, Wielenga V J, Polak M M, van den Berg F M, Adolf G R, Herrlich P, Pals S T, Offerhaus G J
Abstract excerpt
Colorectal tumorigenesis evolves through a series of molecular genetic changes, providing putative markers for tumour progression. This study investigated the relation between expression of the tumour suppressor gene p53 and splice variants v5 and v6 of the cell adhesion molecule CD44 by immunohistochemistry on tissue samples of early adenomas (n = 12), late adneomas (n = 12), Dukes's A and B carcinomas (n = 21),...
Topics
- Adenoma
- Biomarkers, Tumor
- Carrier Proteins
- Colorectal Neoplasms
- Disease Progression
- Exons
- Gene Expression
- Genes, p53
- Humans
- Hyaluronan Receptors
- Immunoenzyme Techniques