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Article

RAG2 is regulated differentially in B and T cells by elements 5' of the promoter.

Proceedings of the National Academy of Sciences of the United States of America - 26 Oct 1999

Monroe R J, Chen F, Ferrini R, Davidson L, Alt F W

Abstract excerpt

To study RAG2 gene regulation in vivo, we developed a blastocyst complementation method in which RAG2-deficient embryonic stem cells were transfected with genomic clones containing RAG2 and then assessed for their ability to generate lymphocytes. A RAG2 genomic clone that contained only the RAG2 promoter sequences rescued V(D)J recombination in RAG2-deficient pro-B cell lines, but did not rescue development of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10535988
DOI: 10.1073/pnas.96.22.12713
PMCID: PMC23063

Genes

RAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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