Evidence for allosteric coupling between the ribosome and repressor binding sites of a translationally regulated mRNA.

doi:10.1021/bi00470a025

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Article

Evidence for allosteric coupling between the ribosome and repressor binding sites of a translationally regulated mRNA.

Biochemistry - 8 May 1990

Tang C K, Draper D E

Abstract excerpt

Escherichia coli ribosomal protein S4 is a translational repressor regulating the expression of four ribosomal genes in the alpha operon. In vitro studies have shown that the protein specifically recognizes an unusual mRNA pseudoknot secondary structure which links sequences upstream and downstre...

Topics

Allosteric Regulation
Base Sequence
Cloning, Molecular
Escherichia coli
Gene Expression Regulation, Bacterial
Genetic Variation
Molecular Sequence Data
Nucleic Acid Conformation
Operon
Plasmids
Protein Biosynthesis
RNA, Messenger
Ribosomal Proteins
Ribosomes
Transcription, Genetic
beta-Galactosidase

Source

Open in PubMed

Identifiers

PMID: 2112408
DOI: 10.1021/bi00470a025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2112408-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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