Article
Evidence for allosteric coupling between the ribosome and repressor binding sites of a translationally regulated mRNA.
Biochemistry - 8 May 1990
Tang C K, Draper D E
Abstract excerpt
Escherichia coli ribosomal protein S4 is a translational repressor regulating the expression of four ribosomal genes in the alpha operon. In vitro studies have shown that the protein specifically recognizes an unusual mRNA pseudoknot secondary structure which links sequences upstream and downstream of the ribosome binding site for rpsM (S13) [Tang, C. K., & Draper, D. E. (1989) Cell 57, 531]. We have prepared...
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