Article
A transcriptional repressor obtained by alternative translation of a trinucleotide repeat.
Nucleic acids research - 11 Jan 1995
Lanz R B, Wieland S, Hug M, Rusconi S
Abstract excerpt
Triplet nucleotide repeats are ubiquitous and rapidly evolving sequences in eucaryotic genomes. They are sporadically found in coding regions of transcription regulators where they become translated in different homopolymeric aminoacid (HPAA) stretches, depending on the local frame. Poly(CAG) yields three different HPAAs (poly Gln, Ser or Ala). Current sequence databases indicate a clear bias in the size and...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- Chimera
- DNA, Complementary
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Peptides
- Promoter Regions, Genetic