Article
Active, interactive, and inactive steroid receptor mutants.
Steroids - 1 Feb 1994
Lanz R B, Hug M, Gola M, Tallone T, Wieland S, Rusconi S
Abstract excerpt
In transient co-transfection assays, there is extensive cross-interaction between glucocorticoid receptor (GR) domains. For example, mutation of the conserved Ile residue at position 484 (rat GR map) to cysteine allows a net separation of transactivation and DNA binding. We also observed that the ligand binding domain plays a key role in cooperative transactivation. Furthermore, some carboxy-located mutations...
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