Article
Mutation of Leu25 and Val27 introduces CC chemokine activity into interleukin-8.
The Journal of biological chemistry - 10 Feb 1995
Lusti-Narasimhan M, Power C A, Allet B, Alouani S, Bacon K B, Mermod J J, Proudfoot A E, Wells T N
Abstract excerpt
Interleukin-8 (IL-8) is a member of the CXC branch of the chemokine superfamily and activates neutrophils but not monocytes. The related CC chemokine branch, which includes monocyte chemoattractant protein-1 (MCP-1) and RANTES are potent chemoattractants for monocytes but not neutrophils. Examina...
Topics
- Amino Acid Sequence
- Base Sequence
- Calcium
- Chemokine CCL5
- Chemotactic Factors
- Chemotaxis, Leukocyte
- Cytokines
- DNA, Complementary
- Humans
- Interleukin-8
- Leucine
- Lymphokines
- Models, Molecular
- Molecular Sequence Data
- Monocyte Chemoattractant Proteins
- Mutation
- Valine