Structure of an antibody-lysozyme complex unexpected effect of conservative mutation.

doi:10.1006/jmbi.1994.0022

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Article

Structure of an antibody-lysozyme complex unexpected effect of conservative mutation.

Journal of molecular biology - 20 Jan 1995

Chacko S, Silverton E, Kam-Morgan L, Smith-Gill S, Cohen G, Davies D

Abstract excerpt

The structure of the complex between the Fab HyHEL-5 and chicken lysozyme revealed a large interface region containing 23 lysozyme and 28 Fab residues. Arg68 of the lysozyme is centrally placed in this interface and theoretical studies together with binding assays of this Fab to different avian l...

Topics

Animals
Aprotinin
Arginine
Binding Sites
Chickens
Crystallography
Hydrogen Bonding
Immunoglobulin Fab Fragments
Macromolecular Substances
Models, Molecular
Muramidase
Mutagenesis, Site-Directed
Mutation
Protein Binding
Recombinant Proteins
Trypsin
Water

Source

Open in PubMed

Identifiers

PMID: 7531245
DOI: 10.1006/jmbi.1994.0022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7531245-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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