Article
Repression of a malignant cell-substratum adhesion phenotype by inhibiting the production of the anti-adhesive proteoglycan, PG-M/versican.
Journal of cell science - 1 Sept 1994
Yamagata M, Kimata K
Abstract excerpt
Malignantly transformed cells usually display a rosette-like morphology of substratum adhesions (called podosomes) and disorganized microfilaments, and are often associated with elevated production of chondroitin sulphate. We previously showed that many tissues and cells express alternatively spliced multiforms of the large chondroitin sulphate proteoglycan termed PG-M (versican is one of the short transcripts)....
Topics
- Actin Cytoskeleton
- Base Sequence
- Bone Neoplasms
- Cell Adhesion
- Cell Movement
- Chondroitin Sulfate Proteoglycans
- Extracellular Matrix Proteins
- Humans
- Lectins, C-Type
- Molecular Sequence Data
- Neoplasm Invasiveness