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Article

Glycosyltransferases involved in the synthesis of MUC-associated metastasis-promoting selectin ligands

13 May 2015

Abstract excerpt

The sialyl Lewis a and x (sLe(a/x)) antigens frequently displayed on the surface of tumor cells are involved in metastasis. Their synthesis has been attributed to altered expression of selective glycosyltransferases. Identification of these glycosyltransferases and the glycoproteins that carry these carbohydrate antigens should help advance our understanding of selectin-mediated cancer metastasis. In this study,...

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PMID: 25972125
DOI: 10.1093/glycob/cwv030

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