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Article

Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype.

Cancer gene therapy - 1 Jul 2001

Krueger S, Kellner U, Buehling F, Roessner A

Abstract excerpt

Alterations in cathepsin L expression and trafficking have been associated with the progression and metastasis of several tumor entities. In the present study, we examined the effects of various cathepsin L antisense (as) phosphorothioate oligonucleotides on both the expression of cathepsin L and the invasive potential of the human osteosarcoma cell line MNNG/HOS. Seven oligonucleotides of 20-bp length each and...

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PMID: 11498774
DOI: 10.1038/sj.cgt.7700341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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