Drosophila GABA-gated chloride channel: modified [3H]EBOB binding site associated with Ala-->Ser or Gly mutants of Rdl subunit.

doi:10.1016/0024-3205(95)00006-r

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Drosophila GABA-gated chloride channel: modified [3H]EBOB binding site associated with Ala-->Ser or Gly mutants of Rdl subunit.

Life sciences - 1 Jan 1995

Cole L M, Roush R T, Casida J E

Abstract excerpt

The non-competitive blocker site of the GABA-gated chloride ion channel in normal susceptible strains of Drosophila melanogaster and simulans binds 4-n-[3H]propyl-4'-ethynylbicycloorthobenzoate ([3H]EBOB) at specific sites with KdS of 1.6-1.9 nM and BmaxS of 171-181 fmol/mg protein. This specific...

Topics

Alanine
Animals
Binding Sites
Bridged Bicyclo Compounds
Bridged Bicyclo Compounds, Heterocyclic
Chloride Channels
Drosophila Proteins
Drosophila melanogaster
Glycine
Insecticide Resistance
Ion Channel Gating
Muscimol
Mutation
Receptors, GABA-A
Serine
Structure-Activity Relationship
Tritium
gamma-Aminobutyric Acid

Source

Open in PubMed

Identifiers

PMID: 7885191
DOI: 10.1016/0024-3205(95)00006-r

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7885191-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics