Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drosophila GABA-gated chloride channel: modified [3H]EBOB binding site associated with Ala-->Ser or Gly mutants of Rdl subunit.

Life sciences - 1 Jan 1995

Cole L M, Roush R T, Casida J E

Abstract excerpt

The non-competitive blocker site of the GABA-gated chloride ion channel in normal susceptible strains of Drosophila melanogaster and simulans binds 4-n-[3H]propyl-4'-ethynylbicycloorthobenzoate ([3H]EBOB) at specific sites with KdS of 1.6-1.9 nM and BmaxS of 171-181 fmol/mg protein. This specific binding of [3H]EBOB is strongly inhibited by: a large number and variety of insecticidal channel blockers at 20 nM...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to Binding Sites
Share to Drosophila melanogaster

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Glycine

Share to Mutation

Share to Serine

Share to Structure-Activity Relationship

Source

Identifiers

PMID: 7885191
DOI: 10.1016/0024-3205(95)00006-r

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drosophila GABA-gated chloride channel: modified [3H]EBOB binding site associated with Ala-->Ser or Gly mutants of Rdl subunit.PMID 7885191Read ↗

A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms.Semantic proximity Read ↗

Knock-in mutagenesis in Drosophila Rdl underscores the critical role of the conserved M3 glycine in mediating the actions of broflanilide and isocycloseram on GABA receptorsSemantic proximity Read ↗

Structural model for gamma-aminobutyric acid receptor noncompetitive antagonist binding: widely diverse structures fit the same site.Semantic proximity Read ↗

G3’MTMD3 in the insect GABA receptor subunit, RDL, confers resistance to broflanilide and fluralanerSemantic proximity Read ↗

Alternative splicing of a Drosophila GABA receptor subunit gene identifies determinants of agonist potency.Semantic proximity Read ↗

Functional validation of A2'N mutation of the RDL GABA receptor against fipronil via molecular modeling and genome engineering in drosophila.Semantic proximity Read ↗

The neonicotinoid imidacloprid, and the pyrethroid deltamethrin, are antagonists of the insect Rdl <scp>GABA</scp> receptorSemantic proximity Read ↗

Conservation of cyclodiene insecticide resistance-associated mutations in insects.Semantic proximity Read ↗

GABA-gated chloride channel mutation (Rdl) induces cholinergic physiological compensation resulting in cross resistance in Drosophila melanogaster.Semantic proximity Read ↗

Minireview: Mode of action of meta-diamide insecticides.Semantic proximity Read ↗

Comparison between the modes of action of novel meta-diamide and macrocyclic lactone insecticides on the RDL GABA receptor.Semantic proximity Read ↗

The antiparasitic isoxazoline A1443 is a potent blocker of insect ligand-gated chloride channels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.