Article
Insights into the synergistic mechanism of target resistance: A case study of N. lugens RDL-GABA receptors and fipronil.
Biophysical chemistry - 1 Oct 2020
Li Ting, Zhou Cong, Zheng Nan, Yang Hongbin, Kuang Guanglin, Shao Xusheng, Li Zhong, Cheng Jiagao
Abstract excerpt
It is known that a single mutation exerts moderate resistance to pesticide, while double mutations (DM) cause severe resistance problem through synergistic effect, and even result in failure application of pesticides. However, little is known about how double mutations would synergistically cause much high resistance level. In this work, computational studies were performed on the interaction of fipronil with N....
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