Article
Variability of EWS chimaeric transcripts in Ewing tumours: a comparison of clinical and molecular data.
British journal of cancer - 1 Nov 1994
Zoubek A, Pfleiderer C, Salzer-Kuntschik M, Amann G, Windhager R, Fink F M, Koscielniak E, Delattre O, Strehl S, Ambros P F
Abstract excerpt
Ewing tumours (ET), including Ewing's sarcoma and peripheral primitive neuroectodermal tumour, are well characterised at the molecular level by a unique chromosomal rearrangement which fuses the EWS gene to one of two closely related ETS proto-oncogenes, FLI-1 or ERG. Expression of the resulting chimaeric transcripts can be readily detected by reversed transcriptase polymerase chain reaction (RT-PCR). This...
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