Article
Cryptic exons as a source of increased diversity of Ewing tumor-associated EWS-FLI1 chimeric products.
Genomics - 15 Sept 1999
Kovar H, Jugovic D, Melot T, Zoubek A, Lenoir G, Fink F M, Philip I, Turc-Carel C, Thomas G, Zucman-Rossi J
Abstract excerpt
In the Ewing family of tumors (EFT), the EWS gene is rearranged with members of the ets oncogene family. Variability in genomic breakpoint locations is the source of significant heterogeneity in fusion product structure. As a consequence of variably included exon sequences from the two partner genes, a variable amount of additional peptide sequence is inserted in between the minimal transforming domains. Some of...
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