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Article

EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma.

1 Apr 1998

Abstract excerpt

PURPOSE: More than 90% of Ewing's sarcomas (ES) contain a fusion of the EWS and FLI1 genes, due to the t(11;22)(q24;q12) translocation. At the molecular level, the EWS-FLI1 rearrangements show great diversity. Specifically, many different combinations of exons from EWS and FLI1 encode in-frame fusion transcripts and result in differences in the length and composition of the chimeric protein, which functions as an...

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Identifiers

PMID: 9552022
DOI: 10.1200/jco.1998.16.4.1248

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