Article
Ewingʼs sarcoma and peripheral primitive neuroectodermal tumors after their genetic union
1 Jul 1998
Abstract excerpt
The Ewing family of tumors has been defined by the presence of an EWS-ets gene rearrangement. Using molecular techniques for the visualization of this aberration, several tumors of unusual location and histology were recently identified and added to this group. Increasing experimental data suggest that EWS-ets fusions act as transforming transcription factors. Subtractive screening of transgenic fibroblasts has...
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