Article
EWS-ERG fusion transcript produced by chromosomal insertion in a Ewing sarcoma.
Genes, chromosomes & cancer - 1 Mar 1997
Kaneko Y, Kobayashi H, Handa M, Satake N, Maseki N
Abstract excerpt
The EWS gene is fused in Ewing sarcoma-like tumors by a chromosomal translocation to one of the four ETS-family genes: FLI1, ERG, ETV1, and E1AF. The orientation of EWS and FLI1 on chromosomes 22 and 11, respectively, is 5' centromeric and 3' telomeric, whereas that of ERG on chromosome 21 is the reverse. Although 10% of Ewing-family tumors express the EWS-ERG fusion transcript, there have been no reports on...
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