Molecular Basis of Clinical Heterogeneity in Neuroblastoma

Abstract excerpt

Neuroblastomas are heterogeneous in terms of both their genotype and their clinical behavior. Recent studies suggest that these two features are related, and that the genotype frequently is predictive of response to treatment or the outcome of the patient. The genetic abnormalities that are characteristic of certain neuroblastomas include: (a) loss of heterozygosity (LOH) for the short arm of chromosome 1,...

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