Structure function relationships in diphtheria toxin channels: II. A residue responsible for the channel's dependence on trans pH.

doi:10.1007/BF00234996

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Article

Structure function relationships in diphtheria toxin channels: II. A residue responsible for the channel's dependence on trans pH.

The Journal of membrane biology - 1 Jan 1994

Mindell J A, Silverman J A, Collier R J, Finkelstein A

Abstract excerpt

Ion-conducting channels formed in lipid bilayers by diphtheria toxin are highly pH dependent. Among other properties, the channel's single channel conductance and selectivity depend on proton concentrations on either side of the membrane. We have previously shown that a 61 amino acid fragment of...

Topics

Diphtheria Toxin
Hydrogen-Ion Concentration
Ion Channels
Lipid Bilayers
Membrane Potentials
Membranes, Artificial
Mutation
Structure-Activity Relationship

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