Article
Topography of the TH5 Segment in the Diphtheria Toxin T-Domain Channel.
The Journal of membrane biology - 1 Apr 2016
Kienker Paul K, Wu Zhengyan, Finkelstein Alan
Abstract excerpt
The translocation domain (T-domain) of diphtheria toxin contains 10 α helices in the aqueous crystal structure. Upon exposure to a planar lipid bilayer under acidic conditions, it inserts to form a channel and transport the attached amino-terminal catalytic domain across the membrane. The TH5, TH8, and TH9 helices form transmembrane segments in the open-channel state, with TH1-TH4 translocated across the...
Topics
- Algorithms
- Cysteine
- Diphtheria Toxin
- Ion Channel Gating
- Lipid Bilayers
- Models, Biological
- Mutation
- Protein Interaction Domains and Motifs