Article
Structure-function relationships in diphtheria toxin channels: III. Residues which affect the cis pH dependence of channel conductance.
The Journal of membrane biology - 1 Jan 1994
Mindell J A, Silverman J A, Collier R J, Finkelstein A
Abstract excerpt
The conductance of channels formed by diphtheria toxin (DT) in lipid bilayer membrane depends strongly on pH. We have previously shown that a 61 amino acid region of the protein, denoted TH8-9, is sufficient to form channels having the same pH-dependent conductance properties as those of whole to...
Topics
- Aspartic Acid
- Diphtheria Toxin
- Glutamates
- Glutamic Acid
- Hydrogen-Ion Concentration
- Ion Channels
- Lipid Bilayers
- Membrane Potentials
- Membranes, Artificial
- Mutation
- Structure-Activity Relationship