Article
Antiviral drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase occur in specific RNA structural regions.
Antimicrobial agents and chemotherapy - 1 Feb 1994
Schinazi R F, Lloyd R M, Ramanathan C S, Taylor E W
Abstract excerpt
A statistically significant correlation exists between the locations of drug resistance mutations (DRMs) observed for various reverse transcriptase inhibitors and features of the secondary structure predicted for the RNA coding for human immunodeficiency virus type 1 reverse transcriptase. The kn...
Topics
- Antiviral Agents
- Base Composition
- Computer Simulation
- Drug Resistance, Microbial
- HIV Reverse Transcriptase
- Models, Chemical
- Mutation
- Nucleic Acid Conformation
- RNA
- RNA-Directed DNA Polymerase