Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antiviral drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase occur in specific RNA structural regions.

Antimicrobial agents and chemotherapy - 1 Feb 1994

Schinazi R F, Lloyd R M, Ramanathan C S, Taylor E W

Abstract excerpt

A statistically significant correlation exists between the locations of drug resistance mutations (DRMs) observed for various reverse transcriptase inhibitors and features of the secondary structure predicted for the RNA coding for human immunodeficiency virus type 1 reverse transcriptase. The known DRMs map onto "unstable" bases, which are predominantly nonhelical regions (i.e., loops, bulges, and bends) of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Base Composition

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Computer Simulation

Share to Drug Resistance, Microbial

Share to HIV Reverse Transcriptase

Share to Mutation

Share to Nucleic Acid Conformation

Source

Open in PubMed Open full text

Identifiers

PMID: 7514854
DOI: 10.1128/AAC.38.2.268
PMCID: PMC284439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antiviral drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase occur in specific RNA structural regions.PMID 7514854Read ↗

Role of murine leukemia virus reverse transcriptase deoxyribonucleoside triphosphate-binding site in retroviral replication and in vivo fidelity.Semantic proximity Read ↗

Mutations in HIV-1 reverse transcriptase affect the errors made in a single cycle of viral replication.Semantic proximity Read ↗

Human Immunodeficiency Virus Reverse Transcriptase: 25 Years of Research, Drug Discovery, and PromiseSemantic proximity Read ↗

The impact of multidideoxynucleoside resistance-conferring mutations in human immunodeficiency virus type 1 reverse transcriptase on polymerase fidelity and error specificity.Semantic proximity Read ↗

The HIV-1 Reverse Transcription (RT) Process as Target for RT InhibitorsSemantic proximity Read ↗

Molecular insights into the mechanisms of HIV-1 reverse transcriptase resistance to nucleoside analogs.Semantic proximity Read ↗

5-Azacytidine Can Induce Lethal Mutagenesis in Human Immunodeficiency Virus Type 1Semantic proximity Read ↗

Structural and biochemical effects of human immunodeficiency virus mutants resistant to non-nucleoside reverse transcriptase inhibitors.Semantic proximity Read ↗

Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance.Semantic proximity Read ↗

Molecular basis of fidelity of DNA synthesis and nucleotide specificity of retroviral reverse transcriptases.Semantic proximity Read ↗

Increasing the CpG dinucleotide abundance in the HIV-1 genomic RNA inhibits viral replicationSemantic proximity Read ↗

The base substitution fidelity of HIV-1 reverse transcriptase on DNA and RNA templates probed with 8-oxo-deoxyguanosine triphosphate.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.