Article
The impact of multidideoxynucleoside resistance-conferring mutations in human immunodeficiency virus type 1 reverse transcriptase on polymerase fidelity and error specificity.
Journal of virology - 1 Apr 1998
Rezende L F, Curr K, Ueno T, Mitsuya H, Prasad V R
Abstract excerpt
Variants of human immunodeficiency virus type 1 (HIV-1) that are highly resistant to a number of nucleoside analog drugs have been shown to develop in some patients receiving 2',3'-dideoxy-3'-azidothymidine therapy in combination with 2',3'-dideoxycytidine or 2',3'-dideoxyinosine. The appearance,...
Topics
- Anti-HIV Agents
- Base Sequence
- DNA, Viral
- Dideoxynucleosides
- Drug Resistance, Microbial
- Drug Resistance, Multiple
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Molecular Sequence Data
- Mutation