Article
Mutation studies with dimethyl nitrosamine in young and old lac I transgenic mice.
Mutation research - 1 Jun 1994
Tinwell H, Lefevre P A, Ashby J
Abstract excerpt
Young adult (approximately 8 w) and old (approximately 72 w) lac I transgenic mice have been exposed to a single oral dose of dimethyl nitrosamine (NDMA). 2.5 h later unscheduled DNA synthesis was observed in the liver of the young animals (19.5 NG; control value -3.4 NG). The frequency of lac I- mutations in the liver of the young animals was elevated 7, 10 and 20 days after dosing. A similar fold-increase in...
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