Mutation studies with dimethyl nitrosamine in young and old lac I transgenic mice.

doi:10.1016/0027-5107(94)90261-5

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Article

Mutation studies with dimethyl nitrosamine in young and old lac I transgenic mice.

Mutation research - 1 Jun 1994

Tinwell H, Lefevre P A, Ashby J

Abstract excerpt

Young adult (approximately 8 w) and old (approximately 72 w) lac I transgenic mice have been exposed to a single oral dose of dimethyl nitrosamine (NDMA). 2.5 h later unscheduled DNA synthesis was observed in the liver of the young animals (19.5 NG; control value -3.4 NG). The frequency of lac I-...

Topics

Age Factors
Animals
DNA
DNA Repair
DNA Transposable Elements
Dimethylnitrosamine
Genetic Vectors
Lac Operon
Liver
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Mutagenesis, Site-Directed
Mutagenicity Tests
Mutagens
Mutation

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