Article
Expression of the zeta protein subunit in CD3- NK effectors derived from human thymus.
Cellular immunology - 1 May 1994
Beecher M S, Baiocchi R A, Linett M L, Krajewski C A, Caligiuri M A
Abstract excerpt
The origin, lineage derivation, and sites of human natural killer (NK) cell differentiation are presently unresolved. The vast majority of NK cells found in peripheral blood have surface membrane expression of CD2 and CD16. Both antigens trigger activation pathways which require the zeta protein, a signal-transducing subunit of the CD3-T cell receptor (CD3-TCR) complex which is found as an isolated homodimer...
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