Article
Notch signaling induces cytoplasmic CD3 epsilon expression in human differentiating NK cells.
Blood - 1 Oct 2007
De Smedt Magda, Taghon Tom, Van de Walle Inge, De Smet Greet, Leclercq Georges, Plum Jean
Abstract excerpt
It has been proposed that heterogeneity in natural killer (NK)-cell phenotype and function can be achieved through distinct thymic and bone marrow pathways of NK-cell development. Here, we show a link between Notch signaling and the generation of intracellular CD3epsilon (cyCD3)-expressing NK cells, a cell population that can be detected in vivo. Differentiation of human CD34(+) cord blood progenitors in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.