Somatically mutated member of the human V lambda VIII gene family encodes anti-myelin-associated glycoprotein (MAG) activity.

Abstract excerpt

A highly conserved small family of human V lambda genes was identified by DNA homology to a V lambda gene isolated from a patient with demyelinating peripheral neuropathy, and which encodes an autoantibody with anti-MAG activity. Comparison of the genes indicates that the patient V lambda gene was derived from one of the germline genes. Together with published analyses of other anti-MAG IgM antibodies, which also...

Topics

• Autoantibodies
• Base Sequence
• DNA
• Humans
• Immunoglobulin Light Chains
• Immunoglobulin Variable Region
• Immunoglobulin lambda-Chains
• Molecular Probes
• Molecular Sequence Data
• Mutation
• Myelin Proteins