Article
One of two Ets-binding sites in the cytokeratin EndoA enhancer is essential for enhancer activity and binds to Ets-2 related proteins.
Nucleic acids research - 25 Feb 1994
Fujimura Y, Yamamoto H, Hamazato F, Nozaki M
Abstract excerpt
Expression of the mouse cytokeratin EndoA gene is restricted in endodermal and epithelial cells, and is regulated by an enhancer that is located 1 kilobase (kb) 3' downstream from the gene. The enhancer consists of six direct repeats, of which each contains two predicted Ets binding sites (EBS1 and EBS2) containing GGAA as a core. Mutation analysis showed that EBS1 is essential for the enhancer activity and...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cell Line
- Chloramphenicol O-Acetyltransferase
- DNA-Binding Proteins
- Enhancer Elements, Genetic
- Keratins
- Mice
- Molecular Sequence Data
- Mutation