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Article

Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis.

Genes & development - 15 Feb 1994

Edgar B A, Sprenger F, Duronio R J, Leopold P, O'Farrell P H

Abstract excerpt

The conserved regulators of cell cycle progression--Cyclins, Cdc2 kinase, and String phosphatase (Cdc25)--accommodate multiple modes of regulation during Drosophila embryogenesis. During cell cycles 2-7, Cdc2/Cyclin complexes are continuously present and show little fluctuation in abundance, phosphomodification, or activity. This suggests that cycling of the mitotic apparatus does not require cytoplasmic...

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Identifiers

PMID: 7510257
DOI: 10.1101/gad.8.4.440
PMCID: PMC6520052

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