Article
Global control of cell-cycle transcription by coupled CDK and network oscillators.
Nature - 12 Jun 2008
Orlando David A, Lin Charles Y, Bernard Allister, Wang Jean Y, Socolar Joshua E S, Iversen Edwin S, Hartemink Alexander J, Haase Steven B
Abstract excerpt
A significant fraction of the Saccharomyces cerevisiae genome is transcribed periodically during the cell division cycle, indicating that properly timed gene expression is important for regulating cell-cycle events. Genomic analyses of the localization and expression dynamics of transcription factors suggest that a network of sequentially expressed transcription factors could control the temporal programme of...
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